Hidden Information Revealed Using the Orthogonal System of Nucleic Acids.

ABSTRACT: In this study, the organization of genetic information in nucleic acids is defined using a novel orthogonal representation. Clearly defined base pairing in DNA allows the linear base chain and sequence to be mathematically transformed into an orthogonal representation where the G-C and A-T pairs are displayed in different planes that are perpendicular to each other. This form of base allocation enables the evaluation of any nucleic acid and predicts the likelihood of a particular region to form non-canonical motifs. The G4Hunter algorithm is currently a popular method of identifying G-quadruplex forming sequences in nucleic acids, and offers promising scores despite its lack of a substantial rational basis. The orthogonal representation described here is an effort to address this incongrui

SUBMITTER: Viglasky V 

PROVIDER: S-EPMC8836696 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature