Tumor Genomic Profiling and Ex Vivo Drug Sensitivity Testing for Pediatric Leukemia and Lymphoma Patients.

ABSTRACT:

Objective

To describe the frequency of use of tumor genomic profiling and functional ex vivo drug sensitivity testing in pediatric patients with hematologic malignancies at our institution, and to determine how the results affected treatment selection.

Methods

A retrospective chart review was conducted to analyze the frequency of tumor genomic profiling and functional drug sensitivity screening in our institution in pediatric patients with hematologic malignancies and to ask if the results were used to direct treatment. A case series of patients for whom these testing recommendations resulted in therapeutic interventions is reported.

Results

Thirty-three patients underwent tumor genomic profiling assays, functional ex vivo testing, or both. Nineteen pati

SUBMITTER: Eaton A 

PROVIDER: S-EPMC8837212 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature