From environmental adaptation to host survival: Attributes that mediate pathogenicity of Candida auris.

ABSTRACT: Candida species are a major cause of invasive fungal infections. While Candida albicans, C. glabrata, C. parapsilosis, and C. tropicalis are the most dominant species causing life-threatening candidiasis, C. auris recently emerged as a new species causing invasive infections with high rates of clinical treatment failures. To mimic initial phases of systemic Candida infections with dissemination via the bloodstream and to elucidate the pathogenic potential of C. auris, we used an ex vivo whole blood infection model. Similar to other clinically relevant Candida spp., C. auris is efficiently killed in human blood, but showed characteristic patterns of immune cell association, survival rates, and cytokine induction. Dual-spe

SUBMITTER: Allert S 

PROVIDER: S-EPMC8837256 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature