Unique spatiotemporal fMRI dynamics in the awake mouse brain.

ABSTRACT: Human imaging studies have shown that spontaneous brain activity exhibits stereotypic spatiotemporal reorganization in awake, conscious conditions with respect to minimally conscious states. However, whether and how this phenomenon can be generalized to lower mammalian species remains unclear. Leveraging a robust protocol for resting-state fMRI (rsfMRI) mapping in non-anesthetized, head-fixed mice, we investigated functional network topography and dynamic structure of spontaneous brain activity in wakeful animals. We found that rsfMRI networks in the awake state, while anatomically comparable to those observed under anesthesia, are topologically configured to maximize interregional communication, departing from the underlying community structure of the mouse axonal connectome. We further r

SUBMITTER: Gutierrez-Barragan D 

PROVIDER: S-EPMC8837277 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature