Bioactive Cellulose Acetate Electrospun Mats as Scaffolds for Bone Tissue Regeneration.

ABSTRACT: In the last decades, cell-based approaches for bone tissue engineering (BTE) have relied on using models that cannot replicate the complexity of the bone microenvironment. There is an ongoing amount of research on scaffold development responding to the need for feasible materials that can mimic the bone extracellular matrix (ECM) and aid bone tissue regeneration (BTR). In this work, a porous cellulose acetate (CA) fiber mat was developed using the electrospinning technique and the mats were chemically modified to bioactivate their surface and promote osteoconduction and osteoinduction. The mats were characterized using FTIR and SEM/EDS to validate the chemical modifications and assess their structural integrity. By coupling adhesive peptides KRSR, RGD, and growth factor BMP-2, the fiber ma

SUBMITTER: Laboy-Lopez S 

PROVIDER: S-EPMC8837436 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature