Prognostic value of preoperative low bone mineral density in patients with digestive cancers: a systematic review and meta-analysis.

ABSTRACT:

Purpose

Osteopenia typically presents low bone mineral density (BMD) and has recently been reported as a prognostic factor in various cancers. However, the prognostic value of osteopenia in digestive tract cancers remains to be defined. We aimed to review the prognostic value of preoperative osteopenia in patients with digestive cancers.

Methods

Cohort studies evaluating the prognostic value of preoperative osteopenia in digestive cancers (colorectal, esophageal, hepatic, bile duct, and pancreatic cancer) were searched using electronic databases and trial registries. The exposure was defined as low BMD estimated by computed tomography at 11^th thoracic vertebra, while comparator was normal BMD. The primary outcomes were overall survival and recurrence-free survival

SUBMITTER: Watanabe J 

PROVIDER: S-EPMC8837550 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature