Prevalence of white matter pathways coming into a single white matter voxel orientation: The bottleneck issue in tractography.

ABSTRACT: Characterizing and understanding the limitations of diffusion MRI fiber tractography is a prerequisite for methodological advances and innovations which will allow these techniques to accurately map the connections of the human brain. The so-called "crossing fiber problem" has received tremendous attention and has continuously triggered the community to develop novel approaches for disentangling distinctly oriented fiber populations. Perhaps an even greater challenge occurs when multiple white matter bundles converge within a single voxel, or throughout a single brain region, and share the same parallel orientation, before diverging and continuing towards their final cortical or sub-cortical terminations. These so-called "bottleneck" regions contribute to the ill-posed nature of the tracto

SUBMITTER: Schilling KG 

PROVIDER: S-EPMC8837578 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature