Altered single-subject gray matter structural networks in drug-naive attention deficit hyperactivity disorder children.

ABSTRACT: Altered topological organization of brain structural covariance networks has been observed in attention deficit hyperactivity disorder (ADHD). However, results have been inconsistent, potentially related to confounding medication effects. In addition, since structural networks are traditionally constructed at the group level, variabilities in individual structural features remain to be well characterized. Structural brain imaging with MRI was performed on 84 drug-naïve children with ADHD and 83 age-matched healthy controls. Single-subject gray matter (GM) networks were obtained based on areal similarities of GM, and network topological properties were analyzed using graph theory. Group differences in each topological metric were compared using nonparametric permutation testing. Compared wi

SUBMITTER: Chen Y 

PROVIDER: S-EPMC8837581 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature