Negative bias effects during audiovisual emotional processing in major depression disorder.

ABSTRACT: Aberrant affective neural processing and negative emotional bias are trait-marks of major depression disorders (MDDs). However, most research on biased emotional perception in depression has only focused on unimodal experimental stimuli, the neural basis of potentially biased emotional processing of multimodal inputs remains unclear. Here, we addressed this issue by implementing an audiovisual emotional task during functional MRI scanning sessions with 37 patients with MDD and 37 gender-, age- and education-matched healthy controls. Participants were asked to distinguish laughing and crying sounds while being exposed to faces with different emotional valences as background. We combined general linear model and psychophysiological interaction analyses to identify abnormal local functional a

SUBMITTER: Li L 

PROVIDER: S-EPMC8837587 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature