Brain opioid segments and striatal patterns of dopamine release induced by naloxone and morphine.

ABSTRACT: Opioid receptors are expressed throughout the brain and play a major role in regulating striatal dopamine (DA) release. Clinical studies have shown that naloxone (NAL, a nonspecific opioid antagonist) in individuals with opioid use disorder and morphine (MRP, a nonspecific opioid agonist) in healthy controls, resulted in DA release in the dorsal and ventral striatum, respectively. It is not known whether the underlying patterns of striatal DA release are associated with the striatal distribution of opioid receptors. We leveraged previously published PET datasets (collected in independent cohorts) to study the brain-wide distribution of opioid receptors and to compare striatal opioid receptor availability with striatal DA release patterns. We identified three major gray matter segments base

SUBMITTER: Shokri-Kojori E 

PROVIDER: S-EPMC8837588 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature