Telomerase is required for glomerular renewal in kidneys of adult mice.

ABSTRACT: Homeostatic renal filtration relies on the integrity of podocytes, which function in glomerular filtration. These highly specialized cells are damaged in 90% of chronic kidney disease, representing the leading cause of end-stage renal failure. Although modest podocyte renewal has been documented in adult mice, the mechanisms regulating this process remain largely unknown and controversial. Using a mouse model of Adriamycin-induced nephropathy, we find that the recovery of filtration function requires up-regulation of the endogenous telomerase component TERT. Previous work has shown that transient overexpression of catalytically inactive TERT (i-TERT^ci mouse model) has an unexpected role in triggering dramatic podocyte proliferation and renewal. We therefore used this model to co

SUBMITTER: Montandon M 

PROVIDER: S-EPMC8837629 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature