Obesity, tidal volume, and pulmonary deposition of fine particulate matter in children with asthma.

ABSTRACT:

Background

Obese children with asthma are more vulnerable to air pollution, especially fine particulate matter (PM_2.5), but reasons are poorly understood. We hypothesised that differences in breathing patterns (tidal volume, respiratory rate and minute ventilation) due to elevated body mass index (BMI) may contribute to this finding.

Objective

To investigate the association of BMI with breathing patterns and deposition of inhaled PM_2.5.

Methods

Baseline data from a prospective study of children with asthma were analysed (n=174). Tidal breathing was measured by a pitot-tube flowmeter, from which tidal volume, respiratory rate and minute ventilation were obtained. The association of BMI z-score with breathing patterns was estimated in a multivariab

SUBMITTER: Afshar-Mohajer N 

PROVIDER: S-EPMC8837716 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature