ASCL1 phosphorylation and ID2 upregulation are roadblocks to glioblastoma stem cell differentiation.

ABSTRACT: The growth of glioblastoma (GBM), one of the deadliest adult cancers, is fuelled by a subpopulation of stem/progenitor cells, which are thought to be the source of resistance and relapse after treatment. Re-engagement of a latent capacity of these cells to re-enter a trajectory resulting in cell differentiation is a potential new therapeutic approach for this devastating disease. ASCL1, a proneural transcription factor, plays a key role in normal brain development and is also expressed in a subset of GBM cells, but fails to engage a full differentiation programme in this context. Here, we investigated the barriers to ASCL1-driven differentiation in GBM stem cells. We see that ASCL1 is highly phosphorylated in GBM stem cells where its expression is compatible with cell proliferation. Howeve

SUBMITTER: Azzarelli R 

PROVIDER: S-EPMC8837758 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature