RYBP regulates Pax6 during in vitro neural differentiation of mouse embryonic stem cells.

ABSTRACT: We have previously reported that RING1 and YY1 binding protein (RYBP) is important for central nervous system development in mice and that Rybp null mutant (Rybp^-/-) mouse embryonic stem (ES) cells form more progenitors and less terminally differentiated neural cells than the wild type cells in vitro. Accelerated progenitor formation coincided with a high level of Pax6 expression in the Rybp^-/- neural cultures. Since Pax6 is a retinoic acid (RA) inducible gene, we have analyzed whether altered RA signaling contributes to the accelerated progenitor formation and impaired differentiation ability of the Rybp^-/- cells. Results suggested that elevated Pax6 expression was driven by the increased activity of the RA signaling pathway in the Rybp^-/- neura

SUBMITTER: Sutus E 

PROVIDER: S-EPMC8837790 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature