Positive Selection and Enhancer Evolution Shaped Lifespan and Body Mass in Great Apes.

ABSTRACT: Within primates, the great apes are outliers both in terms of body size and lifespan, since they include the largest and longest-lived species in the order. Yet, the molecular bases underlying such features are poorly understood. Here, we leveraged an integrated approach to investigate multiple sources of molecular variation across primates, focusing on over 10,000 genes, including approximately 1,500 previously associated with lifespan, and additional approximately 9,000 for which an association with longevity has never been suggested. We analyzed dN/dS rates, positive selection, gene expression (RNA-seq), and gene regulation (ChIP-seq). By analyzing the correlation between dN/dS, maximum lifespan, and body mass, we identified 276 genes whose rate of evolution positively correlates with m

SUBMITTER: Tejada-Martinez D 

PROVIDER: S-EPMC8837823 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature