Exosomes as Natural Nanocarriers for RNA-Based Therapy and Prophylaxis.

ABSTRACT: Exosomes are natural nanocontainers actively secreted by the body's cells and transmitting molecular signals of various types to recipient cells. Cellular mechanisms of exosomes' biogenesis involve specific sorting of RNA for incorporation into them. As a result, the molecular composition of exosomes is closely related to the donor cell's functional state, and this makes exosomes an important diagnostic and prognostic marker in a number of diseases (primarily oncological). The ability of exosomes to transport biologically active molecules and to protect the cargo from degradation makes them nearly ideal candidates as delivery carriers of RNA in therapeutic or prophylactic regimes. Potential of exosomal surface functionalization enables improved targeting to specific organs, tissues and cel

SUBMITTER: Gorshkov A 

PROVIDER: S-EPMC8837954 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature