Understanding Parahydrogen Hyperpolarized Urine Spectra: The Case of Adenosine Derivatives.

ABSTRACT: Parahydrogen hyperpolarization has emerged as a promising tool for sensitivity-enhanced NMR metabolomics. It allows resolution and quantification of NMR signals of certain classes of low-abundance metabolites that would otherwise be undetectable. Applications have been implemented in pharmacokinetics and doping drug detection, demonstrating the versatility of the technique. Yet, in order for the method to be adopted by the analytical community, certain limitations have to be understood and overcome. One such question is NMR signal assignment. At present, the only reliable way to establish the identity of an analyte that gives rise to certain parahydrogen hyperpolarized NMR signals is internal standard addition, which can be laborious. Herein we show that analogously to regular NMR metabolo

SUBMITTER: Ausmees K 

PROVIDER: S-EPMC8837968 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature