Approaches to the Potential Therapy of COVID-19: A General Overview from the Medicinal Chemistry Perspective.

ABSTRACT: In spite of advances in vaccination, control of the COVID-19 pandemic will require the use of pharmacological treatments against SARS-CoV2. Their development needs to consider the existence of two phases in the disease, namely the viral infection and the inflammatory stages. The main targets for antiviral therapeutic intervention are: (a) viral proteins, including the spike (S) protein characteristic of the viral cover and the viral proteases in charge of processing the polyprotein arising from viral genome translation; (b) host proteins, such as those involved in the processes related to viral entry into the host cell and the release of the viral genome inside the cell, the elongation factor eEF1A and importins. The use of antivirals targeted at host proteins is less developed but it has

SUBMITTER: Menendez JC 

PROVIDER: S-EPMC8838458 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature