One-Carbon Metabolism in Alzheimer's Disease and Parkinson's Disease Brain Tissue.

ABSTRACT: Disruptions in one-carbon metabolism and elevated homocysteine have been previously implicated in the development of dementia associated with Alzheimer's disease (AD) and Parkinson's disease (PD). Moreover, a PD diagnosis itself carries substantial risk for the development of dementia. This is the first study that explores alterations in one-carbon metabolism in AD and PD directly in the human brain frontal cortex, the primary center of cognition. Applying targeted liquid chromatography-tandem mass spectrometry (LC-MS/MS), we analyzed post-mortem samples obtained from 136 subjects (35 AD, 65 PD, 36 controls). We found changes in one-carbon metabolites that indicate inefficient activation of cystathionine β-synthase (CBS) in AD and PD subjects with dementia, the latter seemingly accompanied

SUBMITTER: Kalecky K 

PROVIDER: S-EPMC8838558 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature