Effect of Probiotics on Psychiatric Symptoms and Central Nervous System Functions in Human Health and Disease: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

The gut microbiota impacts on central nervous system (CNS) function via the microbiota-gut-brain axis. Thus, therapeutics targeting the gut microbiota such as probiotics have the potential for improving mental health. This meta-analysis synthesizes the evidence regarding the impacts of probiotics on psychological well-being, psychiatric symptoms and CNS functioning.

Methods

The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were applied for executing this review using the databases PubMed, Web of Science and Cochrane Library. The data were summarized at qualitative and quantitative level.

Results

Fifty-four randomized placebo-controlled studies were included, of which 30 were eligible for meta-analysis. If investigated, the pr

SUBMITTER: Le Morvan de Sequeira C 

PROVIDER: S-EPMC8839125 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature