Hippocampal mTOR Dysregulation and Morphological Changes in Male Rats after Fetal Growth Restriction.

ABSTRACT: Fetal growth restriction (FGR) has been linked to long-term neurocognitive impairment, especially in males. To determine possible underlying mechanisms, we examined hippocampal cellular composition and mTOR signaling of male rat FGR offspring during main brain growth and development (postnatal days (PND) 1 and 12). FGR was either induced by a low-protein diet throughout pregnancy, experimental placental insufficiency by bilateral uterine vessel ligation or intrauterine stress by "sham" operation. Offspring after unimpaired gestation served as common controls. Low-protein diet led to a reduced cell density in the molecular dentate gyrus subregion, while intrauterine surgical stress was associated with increased cell density in the cellular CA2 subregion. Experimental placental insufficiency

SUBMITTER: Schomig C 

PROVIDER: S-EPMC8839133 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature