Anti-Inflammatory and Immunoregulatory Action of Sesquiterpene Lactones.

ABSTRACT: Sesquiterpene lactones (SL), characterized by their high prevalence in the Asteraceae family, are one of the major groups of secondary metabolites found in plants. Researchers from distinct research fields, including pharmacology, medicine, and agriculture, are interested in their biological potential. With new SL discovered in the last years, new biological activities have been tested, different action mechanisms (synergistic and/or antagonistic effects), as well as molecular structure-activity relationships described. The review identifies the main sesquiterpene lactones with interconnections between immune responses and anti-inflammatory actions, within different cellular models as well in in vivo studies. Bioaccessibility and bioavailability, as well as molecular structure-activity rel

SUBMITTER: Paco A 

PROVIDER: S-EPMC8839508 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature