Reasons for discontinuing oral anticoagulation therapy for atrial fibrillation: a systematic review.

ABSTRACT:

Introduction

Atrial fibrillation (AF) is the most common cardiac arrhythmia and can lead to significant comorbidities and mortality. Persistence with oral anticoagulation (OAC) is crucial to prevent stroke but rates of discontinuation are high. This systematic review explored underlying reasons for OAC discontinuation.

Methods

A systematic review was undertaken to identify studies that reported factors influencing discontinuation of OAC in AF, in 11 databases, grey literature and backwards citations from eligible studies published between 2000 and 2019. Two reviewers independently screened titles, abstracts and papers against inclusion criteria and extracted data. Study quality was appraised using Gough's weight of evidence framework. Data were synthesised narratively.

Re

SUBMITTER: Buck J 

PROVIDER: S-EPMC8839858 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature