Investigating the Role of Obesity in Prostate Cancer and Identifying Biomarkers for Drug Discovery: Systems Biology and Deep Learning Approaches.

ABSTRACT: Prostate cancer (PCa) is the second most frequently diagnosed cancer for men and is viewed as the fifth leading cause of death worldwide. The body mass index (BMI) is taken as a vital criterion to elucidate the association between obesity and PCa. In this study, systematic methods are employed to investigate how obesity influences the noncutaneous malignancies of PCa. By comparing the core signaling pathways of lean and obese patients with PCa, we are able to investigate the relationships between obesity and pathogenic mechanisms and identify significant biomarkers as drug targets for drug discovery. Regarding drug design specifications, we take drug-target interaction, drug regulation ability, and drug toxicity into account. One deep neural network (DNN)-based drug-target interaction (DTI

SUBMITTER: Yeh SJ 

PROVIDER: S-EPMC8840188 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature