Colorectal cancer development is affected by the ECM molecule EMILIN-2 hinging on macrophage polarization via the TLR-4/MyD88 pathway.

ABSTRACT:

Background

Colorectal cancer is one of the most frequent and deadly tumors. Among the key regulators of CRC growth and progression, the microenvironment has emerged as a crucial player and as a possible route for the development of new therapeutic opportunities. More specifically, the extracellular matrix acts directly on cancer cells and indirectly affecting the behavior of stromal and inflammatory cells, as well as the bioavailability of growth factors. Among the ECM molecules, EMILIN-2 is frequently down-regulated by methylation in CRC and the purpose of this study was to verify the impact of EMILIN-2 loss in CRC development and its possible value as a prognostic biomarker.

Methods

The AOM/DSS CRC protocol was applied to Emilin-2 null and wild type mice. Tumor development

SUBMITTER: Andreuzzi E 

PROVIDER: S-EPMC8840294 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature