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Antidiabetic Potential of Volatile Cinnamon Oil: A Review and Exploration of Mechanisms Using In Silico Molecular Docking Simulations.

ABSTRACT: Cinnamon has been used as a flavoring and medicinal agent for centuries. Much research has focused on cinnamon bark powder, which contains antioxidants, flavonoids, carotenoids, vitamins, minerals, fiber, and small amounts of essential oil. However, isolated and concentrated cinnamon essential oil may also have important medicinal qualities, particularly in antidiabetic therapy. Some of the most common essential oil constituents identified in the literature include cinnamaldehyde, eugenol, and beta-caryophyllene. Due to their high concentration in cinnamon essential oil, these constituents are hypothesized to have the most significant physiological activity. Here, we present a brief review of literature on cinnamon oil and its constituents as they relate to glucose metabolism and diabetic pathogenesis. We also present molecular docking simulations of these cinnamon essential oil constituents (cinnamaldehyde, eugenol, beta-caryophyllene) that suggest interaction with several key enzymes in glucometabolic pathways.

SUBMITTER: Stevens N

PROVIDER: S-EPMC8840343 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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Antidiabetic Potential of Volatile Cinnamon Oil: A Review and Exploration of Mechanisms Using In Silico Molecular Docking Simulations.

Stevens Nicole N Allred Kathryn K

Molecules (Basel, Switzerland) 20220127 3

Cinnamon has been used as a flavoring and medicinal agent for centuries. Much research has focused on cinnamon bark powder, which contains antioxidants, flavonoids, carotenoids, vitamins, minerals, fiber, and small amounts of essential oil. However, isolated and concentrated cinnamon essential oil may also have important medicinal qualities, particularly in antidiabetic therapy. Some of the most common essential oil constituents identified in the literature include cinnamaldehyde, eugenol, and b ...[more]

PMID: 35164117

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Project description:Parasitic nematodes pose a significant global socio-economic threat and contribute to neglected diseases. Current infection control relies on drug therapy, but increasing anthelmintic resistance highlights the urgent need for novel treatments. In this study, we investigate the molecular targets and mechanisms of action of trans-cinnamaldehyde (TCA), a principal component of Cinnamon Essential Oil (Cinnamomum verum EO), using Caenorhabditis elegans as a model organism. Our research offers new insights into the anthelmintic effects of TCA by identifying its specific interactions with key Cys-loop receptors and detailing its inhibitory mechanisms. The anthelmintic activity of C. verum EO and TCA manifests as rapid alterations in locomotor activity and inhibition of egg hatching. TCA screening of mutant worms lacking Cys-loop receptors reveal multiple receptor targets, including the levamisole-sensitive nicotinic ACh receptor (L-AChR), GABA-activated chloride channel (UNC-49) and glutamate-activated chloride channel. The mechanism behind the egg hatching inhibition by TCA remains unclear, as none of the mutants studied were found to be resistant to TCA. Furthermore, TCA increases the paralyzing effects of the anthelmintics levamisole and monepantel in a synergistic manner, offering a route for more effective polytherapy strategies. Electrophysiological studies on C. elegans Cys-loop receptors, in both native and heterologous systems, were used to elucidate the molecular mechanisms of TCA-induced paralysis. TCA reduces ACh- and GABA-elicited macroscopic currents and decreases single-channel activity and open durations of native muscle L-AChR channels, indicating an inhibitory action. Thus, by acting through a different mechanism to that of classical anthelmintics, TCA may be beneficial to counteract resistance in combined anthelmintic therapies. Our findings underscore the potential of the multitarget compound TCA as a valuable tool in integrated pharmacological strategies.

Dataset Information

Antidiabetic Potential of Volatile Cinnamon Oil: A Review and Exploration of Mechanisms Using In Silico Molecular Docking Simulations.

Publications

Antidiabetic Potential of Volatile Cinnamon Oil: A Review and Exploration of Mechanisms Using In Silico Molecular Docking Simulations.

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