Molecular Iodine Supplement Prevents Streptozotocin-Induced Pancreatic Alterations in Mice.

ABSTRACT: Pancreatitis has been implicated in the development and progression of type 2 diabetes and cancer. The pancreas uptakes molecular iodine (I2), which has anti-inflammatory and antioxidant effects. The present work analyzes whether oral I2 supplementation prevents the pancreatic alterations promoted by low doses of streptozotocin (STZ). CD1 mice (12 weeks old) were divided into the following groups: control; STZ (20 mg/kg/day, i.p. for five days); I2 (0.2 mg/Kg/day in drinking water for 15 days); and combined (STZ + I2). Inflammation (Masson's trichrome and periodic acid-Schiff stain), hyperglycemia, decreased β-cells and increased α-cells in pancreas were observed in male and female animals with STZ. These animals also showed pancreatic increases in immune cells and inflammation markers as

SUBMITTER: Rodriguez-Castelan J 

PROVIDER: S-EPMC8840345 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature