Plasma Bead Entrapped Liposomes as a Potential Drug Delivery System to Combat Fungal Infections.

ABSTRACT: Fibrin-based systems offer promises in drug and gene delivery as well as tissue engineering. We established earlier a fibrin-based plasma beads (PB) system as an efficient carrier of drugs and antigens. In the present work, attempts were made to further improve its therapeutic efficacy exploiting innovative ideas, including the use of plasma alginate composite matrices, proteolytic inhibitors, cross linkers, and dual entrapment in various liposomal formulations. In vitro efficacy of the different formulations was examined. Pharmacokinetics of the formulations encapsulating Amphotericin B (AmpB), an antifungal compound, were investigated in Swiss albino mice. While administration of the free AmpB led to its rapid elimination (<72 h), PB/liposome-PB systems were significantly effective in su

SUBMITTER: Fatima MT 

PROVIDER: S-EPMC8840493 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature