Influence of Pre-Dispersion Media on the Batch Reactor Dissolution Behavior of Al2O3 Coated TiO2 (NM-104) and Two ZnO (NM-110 and NM-111) Nanomaterials in Biologically Relevant Test Media.

ABSTRACT: Dissolution plays an important role on pulmonary toxicity of nanomaterials (NMs). The influence of contextual parameters on the results from dissolution testing needs to be identified to improve the generation of relevant and comparable data. This study investigated how pre-dispersions made in water, low-calcium Gamble's solution, phagolysosomal simulant fluid (PSF), and 0.05% bovine serum albumin (BSA) affected the dissolution of the Al2O3 coating on poorly soluble TiO2 also coated with glycerine (NM-104) and rapidly dissolving uncoated (NM-110) and triethoxycaprylsilane-coated ZnO (NM-111) NMs. Dissolution tests were undertaken and controlled in a stirred batch reactor using low-calcium Gamble's solution and phagolysosomal simulant fluid a surrogate for the lung-lining and macrophage pha

SUBMITTER: Holmfred E 

PROVIDER: S-EPMC8840498 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature