Association of significantly elevated plasma levels of NGAL and IGFBP4 in patients with diabetic nephropathy.

ABSTRACT:

Background

Diabetic nephropathy (DN) is a type of progressive kidney disease affecting approximately 40% of patients with diabetes. Current DN diagnostic criteria predominantly rely on albuminuria and serum creatinine (sCr) levels. However, the specificity and reliability of both markers are limited. Hence, reliable biomarkers are required for early diagnosis to effectively manage DN progression.

Methods

In this study, a cohort of 159 individuals were clinically evaluated and the plasma levels of NGAL, IGFBP-1, IGFBP-3, and IGFBP-4 were determined using Multiplexing Assays. Additionally, the association between the plasma levels of NGAL, IGFBP-1, IGFBP-3, and IGFBP-4 in patients with DN were compared to those in patients with T2D without kidney disease and control participan

SUBMITTER: Ali H 

PROVIDER: S-EPMC8840773 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature