Aplysia Neurons as a Model of Alzheimer's Disease: Shared Genes and Differential Expression.

ABSTRACT: Although Alzheimer's disease (AD) is the most common form of dementia in the United States, development of therapeutics has proven difficult. Invertebrate alternatives to current mammalian AD models have been successfully employed to study the etiology of the molecular hallmarks of AD. The marine snail Aplysia californica offers a unique and underutilized system in which to study the physiological, behavioral, and molecular impacts of AD. Mapping of the Aplysia proteome to humans and cross-referencing with two databases of genes of interest in AD research identified 898 potential orthologs of interest in Aplysia. Included among these orthologs were alpha, beta and gamma secretases, amyloid-beta, and tau. Comparison of age-associated differential expression in Aplysia sensory neurons with t

SUBMITTER: Kron NS 

PROVIDER: S-EPMC8840921 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature