Nature's nitrite-to-ammonia expressway, with no stop at dinitrogen.

ABSTRACT: Since the characterization of cytochrome c₅₅₂ as a multiheme nitrite reductase, research on this enzyme has gained major interest. Today, it is known as pentaheme cytochrome c nitrite reductase (NrfA). Part of the NH₄⁺ produced from NO₂^- is released as NH₃ leading to nitrogen loss, similar to denitrification which generates NO, N₂O, and N₂. NH₄⁺ can also be used for assimilatory purposes, thus NrfA contributes to nitrogen retention. It catalyses the six-electron reduction of NO₂^- to NH₄⁺, hosting four His/His ligated c-type hemes for electron transfer and one structurally differentiated active site heme. Catalysis occurs at the distal sid

SUBMITTER: Kroneck PMH 

PROVIDER: S-EPMC8840924 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature