Arterial Stiffness and Vascular Load in HFpEF: Differences Among Women and Men.

ABSTRACT:

Background

Mechanisms underlying sex differences in heart failure with preserved ejection fraction (HFpEF) are poorly understood. We sought to examine sex differences in measures of arterial stiffness and the association of arterial stiffness measures with left ventricular hemodynamic responses to exercise in men and women.

Methods

We studied 83 men (mean age 62 years) and 107 women (mean age 59 years) with HFpEF who underwent cardiopulmonary exercise testing with invasive hemodynamic monitoring and arterial stiffness measurement (augmentation pressure [AP], augmentation index [AIx], and aortic pulse pressure [AoPP]). Sex differences were compared using multivariable linear regression. We examined the association of arterial stiffness with abnormal left ventricular diastolic

SUBMITTER: Lau ES 

PROVIDER: S-EPMC8840989 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature