Immune cell type and DNA methylation vary with reproductive status in women: possible pathways for costs of reproduction.

ABSTRACT:

Background

Consistent with evolutionarily theorized costs of reproduction (CoR), reproductive history in women is associated with life expectancy and susceptibility to certain cancers, autoimmune disorders and metabolic disease. Immunological changes originating during reproduction may help explain some of these relationships.

Methodology

To explore the potential role of the immune system in female CoR, we characterized leukocyte composition and regulatory processes using DNA methylation (DNAm) in a cross-sectional cohort of young (20-22 years old) women differing in reproductive status.

Results

Compared to nulliparity, pregnancy was characterized by differential methylation at 828 sites, 96% of which were hypomethylated and enriched for genes associated with T-cell a

SUBMITTER: Ryan CP 

PROVIDER: S-EPMC8841013 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature