Depletion of RIPK4 parallels higher malignancy potential in cutaneous squamous cell carcinoma.

ABSTRACT:

Background

The RIPK4 (receptor-interacting protein kinase 4), a member of the RIPK family, acts as an important regulator of epidermal differentiation, cutaneous inflammation, and cutaneous wound repair. However, Until now, the role of RIPK4 in tumorigenesis remains elusive. There have been no studies exploring the effects of RIPK4 on the signaling pathway in cutaneous squamous cell carcinoma (SCC). It remains unknown whether RIPK4 expression, which can affect the degree of epidermal differentiation can also influence the radiosensitivity of skin SCC. It is urgent to fully elucidate the biological mechanism by which RIPK4 promotes carcinogenesis in skin SCC and determine whether RIPK4 expression levels predicts the sensitivity to radiotherapy in skin SCC.

Methods

Human skin

SUBMITTER: Xu J 

PROVIDER: S-EPMC8841032 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature