Retinal waves prime visual motion detection by simulating future optic flow.

ABSTRACT: The ability to perceive and respond to environmental stimuli emerges in the absence of sensory experience. Spontaneous retinal activity prior to eye opening guides the refinement of retinotopy and eye-specific segregation in mammals, but its role in the development of higher-order visual response properties remains unclear. Here, we describe a transient window in neonatal mouse development during which the spatial propagation of spontaneous retinal waves resembles the optic flow pattern generated by forward self-motion. We show that wave directionality requires the same circuit components that form the adult direction-selective retinal circuit and that chronic disruption of wave directionality alters the development of direction-selective responses of superior colliculus neurons. These dat

SUBMITTER: Ge X 

PROVIDER: S-EPMC8841103 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature