Human papillomavirus and abnormal cervical lesions among HIV-infected women in HIV-discordant couples from Kenya.

ABSTRACT:

Objective

HIV infection increases the risk of high-grade cervical neoplasia and invasive cervical carcinoma. The study addresses the limited data describing human papillomavirus (HPV) infection and cervical neoplasia among HIV-infected women in HIV-discordant relationships in sub-Saharan Africa, which is needed to inform screening strategies.

Methods

A cross-sectional study of HIV-infected women with HIV-uninfected partners was conducted to determine the distribution of type-specific HPV infection and cervical cytology. This study was nested in a prospective cohort recruited between September 2007 and December 2009 in Nairobi, Kenya. Cervical cells for HPV DNA testing and conventional cervical cytology were collected. HPV types were detected and genotyped by Roche Linear Arr

SUBMITTER: Guthrie BL 

PROVIDER: S-EPMC8841106 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature