MCAM is associated with metastasis and poor prognosis in osteosarcoma by modulating tumor cell migration.

ABSTRACT:

Background

Although there are standard treatment options for osteosarcoma (OS), the prognoses of patients with OS remain varied. Therefore, it is important to profile OS patients at a high risk of mortality to develop focused interventions. Although tumor biomarkers are closely associated with clinical outcomes, data on prognostic biomarkers for OS remain scarce.

Methods

We collected RNA expression profiles and clinical data of 90 OS patients from the GEO database (dataset GSE21257 and GSE39055) and 96 patients in the TARGET program. The data were analyzed using univariate Kaplan-Meier survival analysis to screen candidate gene sets that might be associated with OS survival.

Results

Our analysis demonstrated that melanoma cell adhesion molecule (MCAM) was associated w

SUBMITTER: Du X 

PROVIDER: S-EPMC8841137 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature