Attenuated alpha-gamma coupling in emotional dual pathways with right-Amygdala predicting ineffective antidepressant response.

ABSTRACT:

Aims

The diversity of treatment outcomes for major depressive disorder (MDD) remains uncertain in neuropathology. The current study aimed at exploring electrophysiological biomarkers associated with treatment response.

Methods

The present study recruited 130 subjects including 100 MDD patients and 30 healthy controls. All subjects participated in a sad expression recognition task while their magnetoencephalography data were recorded. Patients who had a reduction of at least 50% in disorder severity at endpoint (>2 weeks) were considered as responders. Within-frequency power and phase-amplitude coupling were measured for the brain regions involved in the emotional visual information processing pathways.

Results

The significant alpha-gamma decoupling from the right thal

SUBMITTER: Dai Z 

PROVIDER: S-EPMC8841302 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature