Ectopic fat deposition in populations of black African ancestry: A systematic review and meta-analysis.

ABSTRACT:

Aims

In populations of black African ancestry (BA), a paradox exists whereby lower visceral adipose tissue is found despite their high risk for type 2 diabetes (T2D). This systematic review investigates ethnic differences in other ectopic fat depots (intrahepatic lipid: IHL; intramyocellular lipid: IMCL and intrapancreatic lipid; IPL) to help contextualise their potential contribution to T2D risk.

Methods

A systematic literature search was performed in December 2020 to identify studies reporting at least one ectopic fat comparison between BA and one/more other ethnicity. For IHL, a meta-analysis was carried out with studies considered comparable based on the method of measurement.

Results

Twenty-eight studies were included (IHL: n = 20; IMCL: n = 8; IPL: n = 4). Meta-

SUBMITTER: Reed RM 

PROVIDER: S-EPMC8841318 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature