The pathophysiology of glucose intolerance in newly diagnosed, untreated T2DM.

ABSTRACT:

Aims

The two predominant pathophysiological defects resulting in glucose intolerance are beta-cell dysfunction and insulin insensitivity. This study aimed to re-examine beta-cell function and insulin sensitivity across a continuum from normal glucose tolerance (NGT) to early type 2 diabetes (T2DM) employing highly specific insulin, C-peptide and intact proinsulin assays.

Materials and methods

A total of 104 persons with NGT, 85 with impaired glucose tolerance (IGT) and 554 with newly diagnosed T2DM were investigated. Following an overnight fast, all underwent a 4-h standardised mixed meal tolerance test (MTT), and on a second day, a sub-group underwent a frequently sampled insulin-modified intravenous glucose tolerance test (FSIVGTT) over a 3-h period. The participants were

SUBMITTER: Dunseath GJ 

PROVIDER: S-EPMC8841334 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature