Imaging Glioblastoma With ¹⁸F-Fluciclovine Amino Acid Positron Emission Tomography.

ABSTRACT:

Introduction

Conventional methods of imaging brain tumors fail to assess metabolically active tumor regions, which limits their capabilities for tumor detection, localization, and response assessment. Positron emission tomography (PET) with ¹⁸F-fluciclovine (fluciclovine) provides regional assessment of amino acid uptake in tumors that could overcome some of the limitations of conventional imaging. However, the biological basis of enhanced fluciclovine uptake is insufficiently characterized in brain tumors, which confounds clinical interpretation and application. This study sought to address this gap by correlating multiple biologic quantities with fluciclovine PET uptake across a range of human glioblastoma xenograft models.

Methods

Thirty-one rats underwent orth

SUBMITTER: Scarpelli ML 

PROVIDER: S-EPMC8841434 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature