A comprehensive profile of TCF1⁺ progenitor and TCF1^- terminally exhausted PD-1⁺CD8⁺ T cells in head and neck squamous cell carcinoma: implications for prognosis and immunotherapy.

ABSTRACT: The heterogeneity of exhausted T cells (Tex) is a critical determinant of immune checkpoint blockade therapy efficacy. However, few studies have explored exhausted T cell subpopulations in human cancers. In the present study, we examined samples from two cohorts of 175 patients with head and neck squamous cell cancer (HNSCC) by multiplex immunohistochemistry (mIHC) to investigate two subsets of Tex, CD8⁺PD1⁺TCF1⁺ progenitor exhausted T cells (TCF1⁺Tex^prog) and CD8⁺PD1⁺TCF1^- terminally exhausted T cells (TCF1^-Tex^term). Moreover, fresh tumor samples from 34 patients with HNSCC were examined by flow cytometry and immunohistochemistry to further investigate their properties and cytotox

SUBMITTER: Wang D 

PROVIDER: S-EPMC8841504 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature