Thalamocortical Mechanisms Regulating the Relationship between Transient Beta Events and Human Tactile Perception.

ABSTRACT: Transient neocortical events with high spectral power in the 15-29 Hz beta band are among the most reliable predictors of sensory perception. Prestimulus beta event rates in primary somatosensory cortex correlate with sensory suppression, most effectively 100-300 ms before stimulus onset. However, the neural mechanisms underlying this perceptual association are unknown. We combined human magnetoencephalography (MEG) measurements with biophysical neural modeling to test potential cellular and circuit mechanisms that underlie observed correlations between prestimulus beta events and tactile detection. Extending prior studies, we found that simulated bursts from higher-order, nonlemniscal thalamus were sufficient to drive beta event generation and to recruit slow supragranular inhibition acti

SUBMITTER: Law RG 

PROVIDER: S-EPMC8841599 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature