GABRA1 and GABRB2 Polymorphisms are Associated with Propofol Susceptibility.

ABSTRACT:

Purpose

To explore the effect of gene polymorphisms of propofol GABA_A receptor and metabolic enzyme on drug susceptibility during the induction period of general anesthesia.

Patients and methods

A total of 294 female patients aged 18-55 years, ASA I-II, who underwent hysteroscopy with intravenous general anesthesia, were included in the study. Anesthesia was induced by continuous intravenous infusion of propofol at 40 mg·kg^-1·h^-1. Infusion of propofol was ended when both the Modified Observer's Assessment of Awareness/Sedation scale (MOAA/S scale) decreased to 1 and the BIS index decreased to 60. The time when the MOAA/S scale decreased to 1 and the time when BIS index decreased to 60 was recorded to assess the susceptibility to the sedation

SUBMITTER: Zeng Y 

PROVIDER: S-EPMC8841664 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature