Metabolic Variation Dictates Cardiac Pathogenesis in Patients With Tetralogy of Fallot.

ABSTRACT:

Background

Herein, we aimed to analyze cardiac metabolic reprogramming in patients with tetralogy of Fallot (ToF).

Methods

Cardiac metabolic reprogramming was analyzed through comprehensive bioinformatics analysis, which included gene set enrichment, gene set variation, and consensus clustering analyses, so as to assess changes in metabolic pathways. In addition, full-spectrum metabolomics analysis was performed using right atrial biopsy samples obtained from patients with ToF and atrial septal defect (ASD) before cardiopulmonary bypass; ultrahigh performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was used to construct a metabolic map of cardiac metabolic reprogramming in cyanotic congenital heart disease.

Results

The metabolic maps of carbohydrat

SUBMITTER: Liu J 

PROVIDER: S-EPMC8841742 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature