Retinal cavitations in macular telangiectasia type 2 (MacTel): longitudinal structure-function correlations.

ABSTRACT:

Background/aims

To quantify retinal cavitation size over time in macular telangiectasia type 2 (MacTel) and to correlate changes with visual acuity and area of ellipsoid zone loss.

Methods

Optical coherence tomography (OCT) macula volume scans from sham eyes included in a prospective, phase II clinical trial of human ciliary neutrophic factor for MacTel at baseline, 1 year and 2 years of follow-up were analysed. Cavitations were segmented by two independent readers. Total cavitation volume was compared with area of ellipsoid zone loss and best-corrected visual acuity (BCVA).

Results

Fifty-one eyes from 51 unique patients (mean age 62 years, range 45-79 years) were included. Intraclass correlation between readers for cavitation volume was excellent (>0.99). Average cav

SUBMITTER: Cai CX 

PROVIDER: S-EPMC8841952 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature