The prognostic significance of anaplasia in childhood rhabdomyosarcoma: A report from the Children's Oncology Group.

ABSTRACT:

Background

Established prognostic indicators in rhabdomyosarcoma (RMS), the most common childhood soft tissue sarcoma, include several clinicopathologic features. Among pathologic features, anaplasia has been suggested as a potential prognostic indicator, but the clinical significance of anaplasia remains unclear.

Methods

Patients enrolled on one of five recent Children's Oncology Group clinical trials for RMS (D9602, n = 357; D9802, n = 80; D9803, n = 462; ARST0331, n = 335; and ARST0531, n = 414) with prospective central pathology review were included in this study. Clinicopathologic variables including demographic information, risk group, histologic subtype, and anaplasia were recorded along with overall survival (OS) and failure-free survival (FFS) with failure defined b

SUBMITTER: Shenoy A 

PROVIDER: S-EPMC8842073 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature