Ontology highlight
ABSTRACT:
SUBMITTER: Foster H
PROVIDER: S-EPMC8842102 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20220120 2
The GPVI platelet receptor was recently validated as a safe antiplatelet target for the treatment of thrombosis using several peptidic modulators. In contrast, few weakly potent small-molecule GPVI antagonists have been reported. Those that have been published often lack evidence for target engagement, and their biological efficacy cannot be compared because of the natural donor variability associated with the assays implemented. Herein, we present the first side-by-side assessment of the report ...[more]