Diagnostic value of Lipoarabinomannan antigen for detecting Mycobacterium tuberculosis in adults and children with or without HIV infection.

ABSTRACT:

Objectives

Even today, tuberculosis (TB) remains a leading public health problem; yet, the current diagnostic methods still have a few shortcomings. Lipoarabinomannan (LAM) provides an opportunity for TB diagnosis, and urine LAM detection seems to have a promising and widely applicable prospect.

Design or methods

Four databases were systematically searched for eligible studies, and the quality of the studies was evaluated using the quality assessment of diagnostic accuracy studies-2 (QUADAS-2). Graphs and tables were created to show sensitivity, specificity, likelihood ratios, diagnostic odds ratio (DOR), the area under the curve (AUC), and so on.

Results

Based on the included 67 studies, the pooled sensitivity of urine LAM was 48% and specificity was 89%. In the subg

SUBMITTER: Yin X 

PROVIDER: S-EPMC8842169 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature